Uptake of L-valyl-L-valine and glycylsarcosine by hamster jejunum in vitro.
نویسندگان
چکیده
منابع مشابه
Evidence for active transport of the dipeptide glycylsarcosine by hamster jejunum in vitro.
1. Glycylsarcosine, a peptide which is slowly hydrolysed by the intestine, is transported into the jejunal mucosal cells of the hamster by an active Na+-dependent process. 2. Uptake of glycylsarcosine is inhibited by L-methionyl-L-methionine but not by L-methionine, suggesting that L-methionyl-L-methionine and glycylsarcosine share an uptake mechanism which is independent of that for free methi...
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1. This paper reports an investigation of whether the dipeptides glycylsarcosine and L-lysyl-L-lysine share 'a single mediated transport mechanism into hamster jejunum, or whether one of these peptides is taken up in part by a mediated mechanism unavailable to the other. The investigation, using rings of everted jejunum in vitro, was carried out at pH 5 in order to reduce brush border and/or in...
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1. This paper reports an investigation of whether the dipeptides glycylsarcosine and L-glutamyl-Lglutamic acid share a single mediated transport mechanism into hamster jejunum, or whether one of these peptides is transported in part by a transport mechanism unavailable to the other. It describes the kinetics of influx of glycylsarcosine and of L-glutamyl-L-glutamic acid into rings of everted ha...
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Peptide transporters (PEPT1 and PEPT2) in epithelia play an important role in the absorption of small peptides and peptide-like drugs. Recently, it was demonstrated that various nonpeptidic compounds can be transported by these transporters. In the present study, we focused on the L-amino acid ester compounds and examined the mechanisms of their interaction with rat PEPTs (rPEPTs) using stable ...
متن کاملKinetics of mucosal influx of glycylsarcosine, glycine and leucine into hamster jejunum and ileum in vitro.
1. This paper describes an investigation of the kinetics of influx of the dipeptide glycylsarcosine and the amino acids glycine and L-leucine into rings of everted hamster small intestine in vitro, in proximal and distal small intestine (jejunum and ileum). Results were expressed per unit wet weight of intestine. 2. At all concentrations studied (0.1--100 mmol/l), influx of glycylsarcosine was ...
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ورودعنوان ژورنال:
- Clinical science
دوره 62 6 شماره
صفحات -
تاریخ انتشار 1982